Why sleep cause cardiovascular disease

Poor sleep is prospectively linked to all-cause and cardiovascular mortality. So why. Recently, Motivala from UCLA Semel Institute in USA found that sleep loss is associated with increase cytokines in sleep deprivation studies and in primary insomnia patients. He said bidirectional communication between the brain and the inmmune system is carried out through a complex network of autonomic nerves, endocrine hormones and cytokines. Disturbed sleep appears to perturb the functioning of this network and therefore contribute to elevations in inflammatory mediators linked to cardiovascular disease.